Abstract
Nanoparticles can be used in numerous therapeutic procedures, including controlled drug delivery and release, thermal therapy, and photo- and sonodynamic therapy. However, such approaches remain limited due to difficulties associated with accurately controlling their therapeutic efficiency and localized consequences. Thus, we propose the use of ultrasound transmission tomography (UTT) measurements following ultrasonic heating when using nanomaterials as mediators. We test various nanomaterials doped to agar tissue-mimicking phantoms to study how they affect the UTT imaging through improving the contrast. Simultaneously, we investigate the suitability of these mediators in relation to the process of ultrasonic heating under the guidance of UTT. The results show that UTT is sensitive to the presence of magnetic nanoparticle-based nanomaterials and induced temperature rises. The combination of an imaging modality based on generally safe and well-known ultrasound-based imaging and the use of nanomaterials as mediators represents our proposal for a new theranostic approach.
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