Abstract
The immediate release of chemotherapeutics at the target site, along with no premature release in circulation is always challenging. The purpose of this study was to develop a stimuli responsive drug delivery system, composed of lipid supported mesoporous silica nanoparticles (MSNPs) for triggered drug release at the target site and simultaneously avoiding the premature release. MSNPs with a higher drug loading capacity and very slow release were designed so as to enhance release by FDA approved US-irradiation. Doxorubicin, as a model drug, and perfluoropentane (PFP) as a US responsive material, were entrapped in the porous structure of MSNPs. Lipid coating enhanced the cellular uptake and in addition provided a gatekeeping effect at the pore opening to reduce premature release. The mechanical and thermal effects of US induced the conversion of liquid PFP to a gaseous form that was able to rupture the lipid layer, resulting in triggered drug release. The prolonged stability profile and non-toxic behavior made them suitable candidate for the delivery of anticancer drugs. This smart system, with the abilities of better cellular uptake and higher cytotoxic effects on US-irradiation, would be a good addition to the applied side of chemotherapeutic advanced drug delivery systems.
Highlights
Lip-mesoporous silica nanoparticles (MSNPs); Optimization and Characterization stained with 300MSNPs, μL of 4′,6-diamidino-2-phenylindole (DAPI) for 25 min incubation
A UV laser of 364 nmsilica was nanoparticles (MSNPs) wereand successfully by theatslight modification of a previused for excitation of DAPI, emissionsprepared were detected
This study involved the successful development of a stimuli responsive drug delivery system where Dox was used as a model drug, PFP as a stimuli responsive agent, US as a stimulus, and lipid coated MSNPs as carriers
Summary
Licensee MDPI, Basel, Switzerland.Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).Recent developments in nanostructures, such as polymeric nanoparticles; liposomes; dendrimers; micelles; and inorganic nanocarriers including gold, quantum dots, iron oxide, and mesoporous silica nanoparticles have become attractive and advantageous systems for drug delivery and biomedical imaging [1]. Smart drug delivery systems are very attractive due to being stimuli responsive, where release of the drug is triggered by physical, mechanical, or chemical means [2,3]. Unfortunately, the treatment of cancer is still elusive and accompanied by certain side effects and drug resistance. The main challenge related to chemotherapeutics is the distribution of drugs in nonspecific healthy tissues, Pharmaceutics 2021, 13, 1396. https://doi.org/10.3390/pharmaceutics13091396 https://www.mdpi.com/journal/pharmaceutics
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