Ultrasound radiomics model-based nomogram for predicting the risk Stratification of gastrointestinal stromal tumors.

Abstract

This study aimed to develop and evaluate a nomogram based on an ultrasound radiomics model to predict the risk grade of gastrointestinal stromal tumors (GISTs). 216 GIST patients pathologically diagnosed between December 2016 and December 2021 were reviewed and divided into a training cohort (n = 163) and a validation cohort (n = 53) in a ratio of 3:1. The tumor region of interest was depicted on each patient’s ultrasound image using ITK-SNAP, and the radiomics features were extracted. By filtering unstable features and using Spearman’s correlation analysis, and the least absolute shrinkage and selection operator algorithm, a radiomics score was derived to predict the malignant potential of GISTs. a radiomics nomogram that combines the radiomics score and clinical ultrasound predictors was constructed and assessed in terms of calibration, discrimination, and clinical usefulness. The radiomics score from ultrasound images was significantly associated with the malignant potential of GISTs. The radiomics nomogram was superior to the clinical ultrasound nomogram and the radiomics score, and it achieved an AUC of 0.90 in the validation cohort. Based on the decision curve analysis, the radiomics nomogram was found to be more clinically significant and useful. A nomogram consisting of radiomics score and the maximum tumor diameter demonstrated the highest accuracy in the prediction of risk grade in GISTs. The outcomes of our study provide vital insights for important preoperative clinical decisions.