Abstract
A rapid and efficient ultrasound-promoted one-pot synthesis of 2'-amino-2-oxo-5'H-spiro(indoline-3,4'- thiochromeno(4,3-b)pyran)-3'-carbonitrile compounds by one-pot three-component reaction had been developed. Structures of all products were characterized by 1 H NMR, 13 C NMR and HRMS. The effect of ultrasound on yield and reaction time had been studied to understand the role of ultrasound in the reaction. The antifungal activity was determined by micro dilution method. Compound 4f exhibited inhibitory activity to Cryptococcus neoformans, Epidermophyton floccosum and Mucor racemosus better than the positive control drug fluconazole. Keywords thiochromanone; ultrasound; spirooxindole; one-pot three-component reaction; antifungal activity
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