Abstract
Series of 1,3-dibenzyl-1H-4,5,6,7-tetrahydro-1,3-diazepinium and 1,4,5,6,7,8-hexahydro-1,3-diazocinium salts derivatives were efficiently synthesized in excellent yields by dehydrogenation of the corresponding N,N'-dibenzyl aminals employing N-bromosuccinimide (NBS) as dehydrogenating agent under ultrasound irradiation. The present methodology has proven to be simple, efficient and environmentally benign. All novel compounds were identified and characterized by 1H and 13C NMR spectra. The synthesized compounds were screened for their antimicrobial activities.
Highlights
Open AccessCyclic amidinium salts (CAS) with a fully saturated backbone (I) have attracted a great deal of interest in recent years
Series of 1,3-dibenzyl-1H-4,5,6,7-tetrahydro-1,3-diazepinium and 1,4,5,6,7,8hexahydro-1,3-diazocinium salts derivatives were efficiently synthesized in excellent yields by dehydrogenation of the corresponding N,N'-dibenzyl aminals employing N-bromosuccinimide (NBS) as dehydrogenating agent under ultrasound irradiation
Most CAS (I) investigated so far are fiveor six-membered rings derived from imidazole (1H-4,5-dihydroimidazolium salts) or pyrimidine (1,4,5,6-tetrahydropyrimidinium salts) (I, n = 0 and 1 respectively) [1]-[5]
Summary
Open AccessCyclic amidinium salts (CAS) with a fully saturated backbone (I) have attracted a great deal of interest in recent years. Most CAS (I) investigated so far are fiveor six-membered rings derived from imidazole (1H-4,5-dihydroimidazolium salts) or pyrimidine (1,4,5,6-tetrahydropyrimidinium salts) (I, n = 0 and 1 respectively) [1]-[5].
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