Abstract
In order to search for new bioactive substances containing 1,3,4-oxadiazole, some 5-aryl-l,3,4-oxadiazole-2-ylsulfanyl derivatives were synthesized from the active intermediate 5-aryl-l,3,4-oxadiazole-2-thiones, obtained from the condensation of aromatic carboxylic acid hydrazides and carbon disulfide at triethylamine alkaline solution catalyzed by propylphosphonic anhydride, followed by reaction with ethyl chloroacetate in alkaline media under ultrasound irradiation in the presence of PEG-400. The structural features were confirmed by IR, 1HNMR spectra and elemental analysis. These compounds have been screened for their good antibacterial activities against Escherichia coli, Staphyhcoccus aureus and Bacillus Subtilis.
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