Ultrasound-Promoted Nanoreagent for Homologous Targeted Synergistic Chemodynamic/Sonodynamic Tumor Therapy

Abstract

The establishment of a tumor theranostic platform with high efficacy is attracting considerable interest in cancer treatment. Nevertheless, considerable obstacles need to be overcome in developing such a platform. In this study, a versatile theranostic system (CM-FMNPs-Cur) was produced utilizing MnO2 nanoflowers, which provided targeted and synergistic therapy for cancer through the incorporation of sonodynamic and chemodynamic therapies. By integrating Fe3O4, MnO2, and curcumin, CM-FMNPs-Cur manifests a substantial amount of reactive oxygen species toward deep-seated cancers. As a sonosensitizer, curcumin was used for chemodynamic therapy (CDT)_and sonodynamic therapy (SDT). In the acidic environment of malignant cells, CM-FMNPs-Cur can decompose into Mn2+ and Fe2+, triggering a Fenton-like reaction and generating ·OH radicals and oxygen. Ameliorating tumor hypoxia also enhanced the effectiveness of SDT in neoplasms. The homologous targeting effect of CM-FMNPs-Cur on cancer cell membranes led to its accumulation in the tumor region. Here, the mutual promotion of CDT and SDT resulted in an amplified therapeutic outcome. All these results revealed the vast potential of CM-FMNPs-Cur for secure and highly effective collaborative tumor treatment, indicating future clinical applications.