Abstract
Ultrasound-mediated gene delivery (UMGD) is a non-invasive gene transfer technique, utilizing high power ultrasound and DNA-bearing microbubbles. Despite modest transfection efficiency, its high organ, tissue specificity, and repeatability make it an attractive therapeutic option. UMGD has been used in a variety of in vivo applications, including cardiac and skeletal muscle, kidney, liver, cerebral, and even lung, and have been studied using many gene vectors, including plasmid, viral, and small interfering RNA. This presentation will focus specifically on cardiac applications using plasmid DNA, including (1) introduction of UMGD in the heart, including optimization of parameters and protocols, (2) UMGD for therapeutic angiogenesis in chronic ischemia, including multi pro-angiogenic gene therapy and combination gene- and progenitor cell-based therapies for chronic hindlimb ischemia, and (3) applications for anti-apoptotic therapy in heart failure and ischemia-reperfusion injury.
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