Abstract
Ultrasound Mediated Drug Delivery for the Management of Oral Diseases in Near Future
Highlights
An efficacious drug delivery system is as important as a potent drug selection for an effective therapeutic outcome [1]
Numerous review articles have outlined the advantages of Oral transmucosal drug delivery (OTDD) system over the conventional drug delivery system which includes ease of use, ease of accessibility, avoidance of first pass metabolism, less chances of systemic adverse drug reaction and a small area of mucosa is targeted [2,5]
Oral cavity consists of regions which are keratinized and the superficial layer of epithelium is composed of differentiated keratinocytes which are shed after the desquamation [10]
Summary
An efficacious drug delivery system is as important as a potent drug selection for an effective therapeutic outcome [1]. Oral transmucosal drug delivery (OTDD) is defined as the administration of pharmaceutically active agents through the oral mucosa to achieve systemic effects [2]. This conception of drug delivery system is used since many years and is successfully used as an alternative to the other oral or injectables drug forms for the treatment of systemic diseases [3]. Low frequency ultrasound (LFU) is one of the most explored methods under OTDD system in recent years and its application as an enhanced trans-epithelial drug delivery system is well- known [5]. The higher frequencies of ultrasound are used for diagnostic imaging, physiotherapy and pulverization of kidney and gallbladder stones [1,8]
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