Abstract

incidence is much higher: 16 in 123 (1:7) in the series of Whitaker and Danks, 9 and 32 in 101(1:3) in the series of Atwell and associates TM (or 11 in 101, i.e., 1:9 if bifid renal pelvis is excluded), The incidence in our patients with HOODS of nine of 12 pyelograms (1:1.3) showing duplications of the urinary collecting system exceeds by far the incidence in the general population and also the expected incidence in families in which a member was discovered to have a double collecting system. Deteriorating kidney function and renal failure have been described in HOODS, in relation with the microscopic and ultramicroscopic lesions found? 7 The recognition of urinary tract duplication as being a part of HOODS will lead to an alertness toward a correctible situation which may be the cause of renal damage through deranged urinary drainage, stasis, and infection. Although the fortuitous concurrence of these two autosomal dominant traits cannot be ruled out with certainty, the findings in our series suggest that duplications of the renal collecting system pertain to the array of anomalies that may occur in the hereditary osteo-onycho-dysplasia syndrome.

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