Abstract
PurposeThe purpose of this clinical study was to evaluate and compare the effectiveness of ultrasound (US)-guided platelet-rich plasma (PRP) injections versus US-guided corticosteroid injections (CSI) in the treatment of greater trochanteric pain syndrome (GTPS).MethodsBetween January 2015 and December 2016, 24 patients with GTPS were enrolled and randomized in two groups (A and B). Group A (study group) patients received US-guided PRP injection treatment, while group B (control group) patients received US-guided CSI treatment. Clinical outcomes in both groups were evaluated and compared using the Visual Analogue Scale (VAS) of pain, the Harris Hip Score (HHS) and the presence or absence of complications at 4, 12, and 24 weeks post-injection. The level of significance was set at p<0.05.ResultsBoth groups showed improved scores (VAS and HHS) compared to the pre-injection period, but patients in group A had a statistically significant (p <0.05) decrease in VAS score and a significantly increased HHS at the last follow-up (24 weeks post-injection). No complications were reported.ConclusionsIn conclusion, patients with GTPS present better and longer-lasting clinical results when treated with US-guided PRP injections compared to those with CSI. Further studies are needed to optimize the technical preparation of PRP, the sample concentration, the number of injections and the time intervals between them, in order to achieve the maximum desired results.
Highlights
Patients with Greater trochanteric pain syndrome (GTPS) present better and longer-lasting clinical results when treated with USguided platelet-rich plasma (PRP) injections compared to those with corticosteroid injections (CSI)
Further studies are needed to optimize the technical preparation of PRP, the sample concentration, the number of injections and the time intervals between them, in order to achieve the maximum desired results
Greater trochanteric pain syndrome (GTPS), known as trochanteric bursitis or gluteal tendinopathy, is a condition characterized by tenderness and pain over the greater trochanter (GT) radiating along the lateral border of the thigh [1]
Summary
Greater trochanteric pain syndrome (GTPS), known as trochanteric bursitis or gluteal tendinopathy, is a condition characterized by tenderness and pain over the greater trochanter (GT) radiating along the lateral border of the thigh [1] It is more common in women aged 40 to 60 years, who are more frequently affected than men in the 4:1 ratio [2]. GTPS was thought to be caused by inflammation of the bursa (trochanteric bursitis), but surgical, histological, and imaging studies have shown that GTPS is attributable to tendinopathy of gluteal muscles (gluteus medius and/or gluteus minimus) and tensor fascia latae muscle Inflammation of these tendons leads to secondary inflammation of the bursa [4]. Another cause is tightness of the iliotibial band, which runs over the GT and can irritate the bursa associated with the gluteal tendons [4]
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