Abstract
Herein, novel manganese sulfide nanoparticles (MnS NPs) decorated reduced graphene oxide (rGOS) nanocomposite have been designed through a facile ultrasound-assisted method and followed by a sonication process. After then, as-synthesized α-MnS@rGOS was characterized by HRTEM, FESEM, XPS, XRD and EIS. Furthermore, the α-MnS@rGOS nanocomposite modified SPCE (screen-printed carbon electrode) shows excellent electrochemical sensing performance towards Parkinson’s disease biomarker of dopamine (DA). Moreover, the fabricated sensor showed a wide linear range for dopamine between 0.02 and 438.6 µM and nanomolar detection limit (3.5 nM). In addition, the α-MnS@rGOS modified SPCE showed selectivity towards the detection of dopamine in presence of a 10-fold higher concentration of other important biomolecules. The nanocomposite film modified SPCE sensor was good stable and reproducible towards the detection of Parkinson's disease biomarker. Furthermore, the as-synthesized α-MnS@rGOS nanocomposite modified SPCE has been applied to the determination of dopamine in human serum, rat serum and pharmaceutical samples with acceptable recoveries.
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