Ultrasound-assisted one-pot synthesis of dihydropyrimid-2-one/thiones catalyzed by zirconyl chloride hexahydrate

Omar Hashim Yahya ,Badie A Ahmed ,Imad A Thanoon

doi:10.33899/edusj.2013.163065

Abstract

Ultrasound-assisted one-pot synthesis of dihydropyrimid-2-one/thiones catalyzed by zirconyl chloride hexahydrate

Highlights

Heterocyclic compounds have so far been synthesized mainly because of their wide range of biological activities. These compounds play an important role in medicinal chemistry, serving as key templates central to the development of numerous important therapeutic agents[1],the interest in the synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPM) and their thio derivatives have received considerable attention due to their attractive pharmacological profiles
Alkaloids containing the dihydropyrimidine structure have been isolated from various marine sources which have shown some interesting biological properties[3]
The first one-pot synthesis of 3,4-dihydropyrimidine was reported by Biginelli in 1893

Summary

Introduction

Heterocyclic compounds have so far been synthesized mainly because of their wide range of biological activities. These compounds play an important role in medicinal chemistry, serving as key templates central to the development of numerous important therapeutic agents[1],the interest in the synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPM) and their thio derivatives have received considerable attention due to their attractive pharmacological profiles. Alkaloids containing the dihydropyrimidine structure have been isolated from various marine sources which have shown some interesting biological properties[3]. The first one-pot synthesis of 3,4-dihydropyrimidine was reported by Biginelli in 1893.

Results

Conclusion