ULTRASOUND ASSISTED GREEN SYNTHESIS OF 2-FURAN-2-YL-4H-CHROMEN-4-ONES FROM CHALCONES

Gopal K Kakade,Suresh G Vedpathak

doi:10.22159/ijcpr.2020v12i3.38312

Abstract

Objective: To report the ultrasound-assisted synthesis of some bioactive 2-furan-2-yl-4H-chromen-4-one derivatives Methods: Oxidative cyclization of chalcones using iodine in dimethyl sulfoxide for the synthesis. Results: Some bioactive 2-furan-2-yl-4H-chromen-4-one derivatives were synthesized from corresponding chalcones in the presence of iodine in dimethyl sulfoxide under ultrasound irradiation at ambient reaction conditions. Conclusion: The use of ultrasound irradiation gave the advantages of higher yields, lower reaction time and simplicity compared to conventional methods for the synthesis of 2-furan-2-yl-4H-chromen-4-one derivatives.

Highlights

Ultrasound-assisted organic synthesis is another "Green" method used in many organic synthetic pathways for high efficiency, low waste, and low energy requirements
Available AR grade chemicals were used for synthesis. 1H NMR and 13C NMR spectra were recorded on 400 MHz Varian Mercury plus 400 MHz FT NMR spectrometer in CDCl3 using signals for residual protons and carbon atoms of the solvent as the references
The intermediate, chalcones were synthesized by reacting equimolar amounts of furfuraldehyde with different 2-hydroxyacetophenones in the presence of 10% potassium hydroxide in ethanol by ClaisenSchmidt condensation

Summary

Introduction

Ultrasound-assisted organic synthesis is another "Green" method used in many organic synthetic pathways for high efficiency, low waste, and low energy requirements. Ultrasound is widely use for improving the traditional reactions that use expensive reagents, strongly acidic conditions, long reaction times, high temperatures, unsatisfactory yields and incompatibility with other functional groups [1]. In this context, the use of ultrasound to accelerate reactions has proven to be a important tool for meeting the Green Chemistry goals of minimization of waste and reduction of energy requirements [2]

Methods

Results

Conclusion