Abstract
Objective: One of the major complications of diabetes is blood vessel disease, termed angiopathy, which is characterized by abnormal angiogenesis. The objective of this study was to discuss the characteristics of lower limb vascular angiopathy and plaque formation in type 2 diabetes patients and finding its relevance to the carotid atherosclerotic plaque formation, thus directing the clinical diagnosis and treatment. Methods: The ultrasonography was used to monitor the patients with carotid artery and lower limb artery. Results: Compared with the control group, decreased blood flow to lower limb and lower limb angiopathy occurred more obviously in dorsal artery of foot than in popliteal artery. The study revealed that the detection rate of the prevalence of carotid atherosclerosis plaque and lower limb arterial plaque and the combination of plaque both carotid and lower limb arteries in diabetic patients was 369:342:296 (about 1.25:1.15:1) and that the prevalence of carotid plaque and lower limb arterial plaque in all subjects with plaque was 71.3%. The risk of plaque formation also had positive correlation with patient’s age. Color Doppler ultrasound had a clinical significance in the early diagnosis and curative effect observation in type 2 diabetes with lower limb angiopathy. The risk of simultaneous plaque formation in both carotid artery and lower extremity artery was greater in type 2 diabetes than that of control subjects, but they were not necessarily to occur simultaneously. The symptoms were inconspicuous in the early course of diabetes. Conclusion: The application of ultrasound monitoring in patients with carotid artery and lower limb artery might play a role in early warning, delaying the occurrence of macrovascular diseases, and slowing down the development of macroangiopathy such as cerebral infarction and diabetic foot and so on, thus providing a significant basis for clinical diagnosis and treatment.
Highlights
The incidence of lower limb angiopathy diseases in diabetic patients increases obviously which was the principal cause for the block or even amputation in lower limb artery.[1,2] it is the key point in preventing and managing diabetes to reduce diabetic chronic complications as far as possible
The objective of this study was to discuss the characteristics of lower limb vascular angiopathy and plaque formation in type 2 diabetes patients and finding its relevance to the carotid atherosclerotic plaque formation, directing the clinical diagnosis and treatment
As far as diagnostic criteria was concerned, the patients aged less than 88 years old and were in line with the type 2 diabetes mellitus (T2DM) diagnosis standard delivered by World Health Organization (WHO) in October, 1999
Summary
The incidence of lower limb angiopathy diseases in diabetic patients increases obviously which was the principal cause for the block or even amputation in lower limb artery.[1,2] it is the key point in preventing and managing diabetes to reduce diabetic chronic complications as far as possible. The study applies Color Doppler Ultrasound scanning, a kind of simple, convenient and feasible noninvasive technique, which can accurately locate and observe the characteristics of vascular lesions and the plaque formation in lower limbs of the patients with diabetes. It can detect and differentiate the formation of carotid atherosclerotic plaque, find out the potential risk factors in patients with diabetes, and provide basis for early clinical diagnosis and treatment as well as rehabilitation and intervention. The objective of this study was to discuss the characteristics of lower limb vascular angiopathy and plaque formation in type 2 diabetes patients and finding its relevance to the carotid atherosclerotic plaque formation, directing the clinical diagnosis and treatment
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