Abstract
We would like to thank to the Faculty of Specialized Veterinary Sciences research council. Science and Research Branch of Islamic Azad University, Punak Tehran for approval and financial support to finish this project. Problems statement: The purpose of this research was to determine the biological effect of cartilage graft as a bone defect filler and osteogenetic stimulation to speed up bone healing too. Approach: Sixteen adult male New Zealand white rabbits having body weight ranged from 3.0-3.5 Kg. Under general anesthesia, a segmental full thickness bone defect of 10 mm in length was created in the middle of the right radial shaft in all rabbits. They were divided into two groups of 6 rabbits each. Group I was considered as control and the fractured site was fixed using finger bone plate with 4 screws, whereas the ear cartilage of 1×1 cm graft was used to fill the gap after fracture fixation in Group II. Rabbits in two groups were subdivided into 2 subgroups of 1 and 2 months duration with 4 rabbits in each. Radiography and two dimensional and color Doppler sonography were done before and after creating defects and on 15, 30 and 60 days to evaluate local reaction as far as new blood vessels network and callus formation are concerned. Results: On the radiographs during the whole process, bone repair in Group I was not as perfect as those in Group II samples and trace of internal callus filled the gap incompletely in 60 days in Group I, whereas in Group II internal callus almost was formed on 30 days and in addition intercortical callus was seen supporting to cover and filled the gap completely in this group. Sonographic findings confirmed the protrusion of newly formed blood vascular network in 30 days in Group I and from 15 days in Group II and remarkably increased till end of observation period. Conclusion: Cartilage graft is suitable alternative bone filler and radiography and sonography are reliable techniques to trace local reaction at proper time.
Highlights
The skeleton is strong enough but occasional fractures has been reported many times
Skin incision was given on the latero medial surface of right radial bone and after separation of connective tissues and fascia a segmental full thickness bone defect of 10 mm in length was created in the middle of the right radial shaft in all rabbits (Fig. 1)
Radiography and two dimensional and color Doppler sonography were done before experiment, after fixation and on 15, 30 and 60 days and interpretation were done by considering dislocation of graft, new-bone formation and new blood vascular network formation
Summary
The skeleton is strong enough but occasional fractures has been reported many times. The healing processes of the fractures are main clinical problem in human and animals (Barden and Brinker, 1976; De Lutio di et al, 1993; Dickens et al, 1994; Fery-Lemonier et al, 1993; Anast et al, 1958; Friedrich and Volkenstein, 1991). In the last two decades osteografts and replacements in healing spongy bones and compact bones in osteopathy has prevail (Morgan and Leighton, 1997). Many synthetics have developed in osteopathy and replacements They had been used as implements in osteoectomy that investigated experimentally on animals (Toal, 1994). They enforce ossification, three dimensioned vascular genesis, capillary genesis and host intramembranous ossification in grafts.
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