Abstract
Polycystic ovary syndrome (PCOS) is considered as a common cause of hormonal disturbance and obesity. The diagnosis of PCOS was done by different methods including clinical signs as anovulation, hyperandrogenism, biochemical markers and ultrasounographic investigation. This study investigated comparative outcomes of ultrasonographic and biochemical markers for early prediction of PCOS in obese women. Seventy-five patients were clinically diagnosed with obese, PCOS and obese with PCOS and twenty-five normal age matched subjects were enrolled as control. Abdominal and transvaginal ultrasonographic for assessment of ovarian properties. In addition, BMI, serum free testosterone, dehydroepiandrosterone (DHEA), insulin, glycosylated hemoglobin (HbA1c) and LDL-c levels were evaluated. In obese patients with PCOs (20%) ovaries revealed normal appearance in morphology while the rest (80%) showed PCOs in the form of cysts of 2-8 mm in diameter peripherally arranged around stroma. A significant elevation of free testosterone, DHEA and insulin in obese with or without PCOS compared with obese group (p<0.001). A positive correlation with hormonal abnormalities of increased HA1c, LDL-c, free testosterone, DHEA and insulin compared with obese only. According to our study findings, ovarian morphology combined with biochemical markers is more reliable for early prediction and diagnosis of PCOS for interpretation and management.
Highlights
The Polycystic ovary syndrome (PCOS) is considered as a common disturbance of sexual hormonal system1.The diagnosis of PCOS was done by different methods including chronic anovulation, hyperandrogenism and by ultrasonography
This study investigated comparative outcomes of ultrasonographic and biochemical markers for early prediction of PCOS in obese women
The ovarian volume was statistically higher in obese with PCOs than non-obese (p
Summary
The Polycystic ovary syndrome (PCOS) is considered as a common disturbance of sexual hormonal system. The diagnosis of PCOS was done by different methods including chronic anovulation, hyperandrogenism and by ultrasonography. PCOS is the majority causes of female infertility which is a risks factor of metabolic syndrome, diabetes mellitus, cardiovascular diseases and some cancer. Insulin resistance and hyper-insulinemia play a role in the incidence of PCOS4. The insulin resistance in PCOS was higher in obese women without PCOS5 and is a common feature of PCOS in both normal and obese women.
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