Abstract
In the present study, biocompatible manganese nanoparticles have been linked with zinc and iron molecules to prepare different derivatives of Mn0.5Zn0.5ErxYxFe2−2xO4 NPs (x = 0.02, 0.04, 0.06, 0.08, 0.10), using an ultrasonication approach. The structure, surface morphology, and chemical compositions of Mn0.5Zn0.5ErxYxFe2−2xO4 NPs were elucidated by X-ray diffractometer (XRD), High-resolution transmission electron microscopy (HR-TEM), scanning electron microscope (SEM), and Energy Dispersive X-Ray Analysis (EDX) techniques. The bioactivity of Mn0.5Zn0.5ErxYxFe2−2xO4 NPs on normal (HEK-293) and (HCT-116) colon cancer cell line was evaluated. The Mn0.5Zn0.5ErxYxFe2−2xO4 NPs treatment post 48 h resulted in a significant reduction in cells (via MTT assay, having an IC50 value between 0.88 µg/mL and 2.40 µg/mL). The specificity of Mn0.5Zn0.5ErxYxFe2−2xO4 NPs were studied by treating them on normal cells line (HEK-293). The results showed that Mn0.5Zn0.5ErxYxFe2−2xO4 NPs did not incur any effect on HEK-293, which suggests that Mn0.5Zn0.5ErxYxFe2−2xO4 NPs selectively targeted the colon cancerous cells. Using Candida albicans, antifungal activity was also studied by evaluating minimum inhibitory/fungicidal concentration (MIC/MFC) and the effect of nanomaterial on the germ tube formation, which exhibited that NPs significantly inhibited the growth and germ tube formation. The obtained results hold the potential to design nanoparticles that lead to efficient bioactivity.
Highlights
The surface morphology and structure of Mn0.5 Zn0.5 Erx Yx Fe2−2x O4 NPs were attributed by the Energy Dispersive X-Ray Analysis (EDX), scanning electron microscope (SEM), TEM, and X-ray diffractometer (XRD) methods
Mn0.5 Zn0.5 Erx Yx Fe2−2x O4 NPs treatment post 48 h resulted in the significant reduction in cancer cells via MTT assay, having an IC50 value between 0.88 μg/mL and 2.40 μg/mL
The specificity of Mn0.5 Zn0.5 Erx Yx Fe2−2x O4 NPs was studied by treating them on normal cells line (HEK-293)
Summary
Many approaches were developed to customize and synthesize different metallic nanoparticles (MNPs), which are useful in drug design and delivery, experimen-. There are basically few approaches to synthesize MNPs, such as coprecipitation, hydrothermal, citrate assisted auto-combustion, microwave synthesis, reverse micelle, sol-gel, and ultrasonication [4,5,6,7,8]. Among these techniques, ultrasonic approach is the more efficient method to synthesize the homogenized dispersed phase, small particles with better de-agglomeration capability. The method of ultrasonication, firstly, helps to produce high-purity materials, and secondly, from the economic view, it consumes less raw materials with an improved reaction rate [9]
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