Abstract
The methodology of preparation and irradiation by focused ultrasound of brain structures in human patients to favorably modify symptoms of various neurological disorders will be described. This includes the method of brain landmarks location and subsequent geometric positioning of the focus of the ultrasonic beam in arrays of sites in specific structures. The determination of values for the irradiation parameters appropriate for producing selective changes in the tissue components, including the control of auxiliary physical variables which specify the state of the tissue during exposure, will be discussed. Design characteristics of the irradiation, calibration, positioning, and control instrumentation necessary to achieve optimum effects at the present time will be outlined. The techniques and results of irradiation will be illustrated by a motion picture showing human patients undergoing treatment. The modification of abnormal involuntary movements during successive ultrasonic treatment sequences in individuals suffering from Parkinsonism and dystonia musculorum deformans will constitute the clinical material of the motion picture.
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