Ultrasonic Extraction of Tropane Alkaloids from Radix physochlainae Using as Extractant an Ionic Liquid with Similar Structure.

Alula Yohannes,Baohui Zhang,Shun Yao,Bing Dong

doi:10.3390/molecules24162897

Alula Yohannes, Baohui Zhang + Show 2 more

Open Access

https://doi.org/10.3390/molecules24162897

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Abstract

In this research, tropane alkaloids in Radix physochlainae were extracted by tropine-type ionic liquid (IL) aqueous solutions under ultrasound assistance, and N-propyltropine hexafluorophosphate ([C3Tr][PF6]) was found to be the most ideal IL in this extraction mode after comprehensive screening. When 0.03 mol/L [C3Tr][PF6] aqueous solution was chosen as the extraction solvent, the solid-liquid ratio of raw material powders and ionic liquid aqueous solution was 1:20 (g/mL), ultrasonic power was 90 W and extraction time was 30 min, the extraction efficiency of tropane alkaloids has reached 121.3%. Compared with common heating extraction, it can further shorten the extraction time, improve extraction efficiency and decrease IL consumption. Furthermore, extraction mechanism together with potential toxicity of IL have been explored and discussed.

Highlights

Since the last decade, the extraction of natural products driven by new technologies is still a hot research topic, attracting more and more attention from academia and industry [1,2]
The hydrophobic anion of PF6 - has been proven to very suitable for the extraction of those low-polar constituents such as tropane alkaloids, so only the change of cation in ionic liquid (IL) was considered which could provide different intermolecular interaction
It can be seen from the graph that the extraction efficiency of [C3 Tr][PF6 ] is still the best, which indicates different extraction modes have little influence on the overall performance of the extractants

Summary

Introduction

The extraction of natural products driven by new technologies is still a hot research topic, attracting more and more attention from academia and industry [1,2]. Compared with traditional organic solvents, ionic liquids can improve the extraction efficiency of bioactive constituents to a higher extent. They can form hydrogen bonds with the cellulose of plant material cells, strengthen mass transfer and interact with target molecules through noncovalent binding, so that more active components will be extracted efficiently from the internal cells. The solubility of ILs can be improved by adjusting the combination of anions and cations to satisfy the interaction with different substances, thereby improving the separation efficiency They can be recovered through back extraction, crystallization, adsorption or electrochemical methods after extraction. It should be acknowledged that ILs are becoming more and more popular in this area and the review of Ventura and colleagues has comprehensively summarized related basic trends in recent decades [4], which prove they have broad application prospects with obvious advantages over traditional solvents

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Conclusion