Abstract
This review is dedicated to the memory of Dr. Sergei L’vovich Grokhovsky, who was a distinguished scientists and experimenter; it briefly describes one aspect of his multifaceted research activity. Gro-khovsky was the first to describe the specificity of ultrasound-induced cleavage of internucleotide bonds in double-stranded B-DNA. The discovery of this new physicochemical phenomenon made it possible to associate the cleavage effects with conformational and dynamic features of B-DNA nucleotide sequences and provided a new basis for bioinformatics genome analyses. Certain conformational dynamic specifics are characteristic of functional DNA regions; this makes it possible to formulate and solve a number of problems of epigenetics and carcinogenesis.
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