Abstract
Abstract The ultrasmall nanoparticles easily lead to a more seriously response than larger nanoparticles because of their physicochemical features. It is essential to understand their cytotoxicity effects for their further application. Here, we used ultrasmall 9 nm Fe3O4 NPs to explore its cytotoxicity mechanism on breast cancer cells. We demonstrated 9 nm Fe3O4 NPswas effectively internalized into cells and located in nucleus, subsequently, it inhibited DNA synthesis through inducing S-phase arrest.Moreover, 9 nm Fe3O4 NPs induced ROS production and oxidative damage by disturbing the expression of antioxidant-related genes (HMOX-1, GCLC and GCLM), which resulted in the enhancement of cells apoptosis and inhibition of cell proliferation, suggesting its potential to be used as therapeutic drug.
Highlights
The ultrasmall nanoparticles lead to a more seriously response than larger nanoparticles because of their physicochemical features
9 nm Fe3O4 NPs induced reactive oxygen species (ROS) production and oxidative damage by disturbing the expression of antioxidantrelated genes (HMOX-1, GCLC and GCLM), which resulted in the enhancement of cells apoptosis and inhibition of cell proliferation, suggesting its potential to be used as therapeutic drug
We discovered that the Fe3O4 NPs with 9 nm size, it could inhibit the proliferation through enhancing oxidative stress apoptosis of MCF-7 breast cancer cell and disturbing cell cycle (Figure 1)
Summary
Abstract: The ultrasmall nanoparticles lead to a more seriously response than larger nanoparticles because of their physicochemical features. We used ultrasmall 9 nm Fe3O4 NPs to explore its cytotoxicity mechanism on breast cancer cells. 9 nm Fe3O4 NPs induced ROS production and oxidative damage by disturbing the expression of antioxidantrelated genes (HMOX-1, GCLC and GCLM), which resulted in the enhancement of cells apoptosis and inhibition of cell proliferation, suggesting its potential to be used as therapeutic drug. We used ultrasmall Fe3O4 nanoparticles (Fe3O4 NPs) with 9 nm size to investigate the interaction mechanism of ultrasmall nanoparticles with MCF-7 breast cancer cell. We discovered that the Fe3O4 NPs with 9 nm size, it could inhibit the proliferation through enhancing oxidative stress apoptosis of MCF-7 breast cancer cell and disturbing cell cycle (Figure 1). This research contributes to further illustrate the mechanism of Fe3O4 NPs inhibiting MCF-7 breast cancer cells, and suggests the Fe3O4 NPs alone have potential as an antitumor drug to kill tumor
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