Abstract
Novel pH responsive copolymers with tertiary amine groups were prepared by free radical polymerization with 2-(dialkylamino)ethyl methacrylate monomers. These polymers were pH sensitive with the ability to be responsively fine-tuned in aqueous solution, which was proven through titration, transmittance measurements, and proton nuclear magnetic resonance spectroscopy. The polymers were soluble in water at low pH values, induced by electrostatic repulsion between amine groups, and aggregated above their pKa value due to the hydrophobic effect of the alkyls. The pH responsive values were precisely tuned from 7.4 to 4.8 by increasing the hydrophobic monomer ratio. Our work provides a novel approach for the development of ultrasensitive pH-responsive polymers for application in biomedical materials.
Highlights
Introductionpoly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) dissolves in acidic aqueous solution due to facedthe by electrostatic these widely used polybases thatprotonated their phase transition values from the solution state to the repulsions betweenisthe amine groups, but undergoes a precipitation precipitation state are usually fixed
The development of tumor-targeted drug delivery systems have attracted increasing interest given their potential to address therapeutic issues in clinical practice [1,2,3,4,5,6,7]
poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) dissolves in acidic aqueous solution due to facedthe by electrostatic these widely used polybases thatprotonated their phase transition values from the solution state to the repulsions betweenisthe amine groups, but undergoes a precipitation precipitation state are usually fixed
Summary
PDEAEMA dissolves in acidic aqueous solution due to facedthe by electrostatic these widely used polybases thatprotonated their phase transition values from the solution state to the repulsions betweenisthe amine groups, but undergoes a precipitation precipitation state are usually fixed. They are less accurate when targeting cell organelles above pH 7.5, caused by the hydrophobic effect of substituted ethyl group. We developed a series of novel reversible pH-responsive (co)polymers with a finepolymerization method with amine-based monomers,using These polymers were synthesized a free radical polymerization and 2-(dimethylamino)ethyl methacrylate. Range can be controlled within a very narrowly defined value
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