Abstract
High signal amplification is essential for ultrasensitive detection of biomolecules. In recent years, we have developed new redox cycling schemes combined with enzymatic amplification that allow high signal amplification in a simple format along with low background levels. To minimize unwanted side reactions, a new concept that outer-sphere-reaction-philic species can react slowly with inner-sphere-reaction-philic species was applied. In this presentation, the signal amplification based on (i) electrochemical-chemical (EC) redox cycling using a reducing agent, (ii) electrochemical-chemical-chemical (ECC) redox cycling using a reducing agent and an oxidizing agent, and (iii) electrochemical-enzymatic (EN) redox cycling using a redox enzyme will be introduced. Moreover, our efforts for practically useful biosensors (lateral-flow immunosensors and washing-free immunosensors) will be presented.
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