Ultrasensitive Biomolecule‐Less Nanosensor Based on β‐Cyclodextrin/Quinoline Decorated Graphene Oxide toward Prompt and Differentiable Detection of Corona and Influenza Viruses

Abstract

AbstractRapid mutation of airborne pathogenic viruses, e.g., SARS‐CoV‐2, and their similar symptoms with flu or influenza, raises an urgent demand for the development of biomolecule‐less nanosensors capable of rapid, sensitive, specific, and differentiable detection of viruses in a single potential window to distinguish infected people from healthy ones through a precise and prompt manner that do not require highly purified biological receptors. To address this vital requirement, a label‐free, and biomolecule‐less nanosensor is designed and developed based on the modified graphene oxide (GO) with NHS/EDC activated β‐cyclodextrin/8 hydroxyquinoline (8HQ) complex toward rapid (in 1 min) and differentiable detection of betacoronaviruses (viz., SARS‐CoV‐2) and influenza viruses (viz., H1N1 and H3N2) in a single potential window. The outcome of the process shows that the employed process leads to considerable soar in the electrical conductivity, porosity, active surface area, available active sites for trapping viruses, and sensitivity of the nanosensor that leads to rapid, sensitive, specific, and simultaneous detection of selected pathogenic viruses with a superiorly low detection limit (DL) and high sensitivity. Obtained results highlight the potential of the developed nanoplatform as a capable screening tool for quick detection of infected people.