Abstract
At present, the determination of dopamine (DA) is enormously necessary for the human body. Since then, it has played a crucial role in the brain that affects mood, sleep, memory, learning, and concentration. Dopamine insufficiency is a threat to human health. Dopamine recognition is important to avoid this problem. Copper oxide (CuO) nanoparticles are one of the potentials which can be used in the detection of dopamine level in the sample. In this work, CuO was synthesized by a simple chemical precipitation technique and modified by polyvinyl alcohol (PVA) as a capping agent. The nanomaterials manufactured are used for the detection of dopamine in 0.1 M PBS medium at room temperature. The CuO/PVA-modified electrode shows better electrocatalytic activity than CuO/GCE (glassy carbon electrode). The constructed dopamine biosensor of copper oxide-PVA nanocomposites also has extraordinary selectivity, stability, sensitivity (183.12 μA mM-1 cm-2), and a minimum level detection limit of 0.017 μM, is inexpensive, and has minimal effort and rapid detection of dopamine.
Highlights
The biomolecules are playing a significant role in the human body
When dopamine levels are diminished in the human body, it causes Parkinson and schizophrenic diseases [1]
2.4 g of 0.1 M copper nitrate trihydrate was dissolved in 100 mL of distilled water (DW), and 0.8 g of 0.2 M NaOH was dissolved in 100 mL of DW separately
Summary
The biomolecules are playing a significant role in the human body. They are involved in metabolic processes, and some of them act as neurotransmitters, neuroactive molecules, etc. Metal oxide based on electrochemical sensors received huge attention towards dopamine detection [2]. A polymer-incorporated nanomaterial is frequently utilized to ameliorate the conductivity and catalytic tendency of sensors and to drastically increase the strength of the electrochemical transmission when developing nanocomposites based on metal oxide/copper oxide [9]. Polymers such as PEG [10], PVP [11], PVA [12], PAA [13], and polyaniline (PANI) [14] are effectively used in the fabrication of a biosensor. A CuO/PVA-modified GCE-based electrochemical sensor was established for the detection of dopamine
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
