Abstract
Conventional magnetic resonance imaging (MRI) at 1.5 Tesla (T) is limited by modest spatial resolution and signal-to-noise ratio (SNR), impeding the identification and classification of inflammatory central nervous system changes in current clinical practice. Gaining from enhanced susceptibility effects and improved SNR, ultrahigh field MRI at 7 T depicts inflammatory brain lesions in great detail. This review summarises recent reports on 7 T MRI in neuroinflammatory diseases and addresses the question as to whether ultrahigh field MRI may eventually improve clinical decision-making and personalised disease management.
Highlights
Magnetic resonance imaging (MRI) revolutionised clinical neuroimmunology since brain MRI depicted multiple sclerosis (MS) lesions already in early technical developmental stages at 0.1 Tesla (T) [1]
Today’s physicians are faced with a key issue in clinical neurology: many distinct central nervous system (CNS) diseases are characterised by nearly identically appearing white matter changes and brain lesions that are often unspecific in appearance, limiting the diagnostic value of conventional MRI
Following the recommendations of the "EPMA White Paper" [4], this review summarises technical opportunities, challenges, and findings of recent clinical 7 T MRI studies on multiple sclerosis, neuromyelitis optica, and Susac syndrome
Summary
Magnetic resonance imaging (MRI) revolutionised clinical neuroimmunology since brain MRI depicted multiple sclerosis (MS) lesions already in early technical developmental stages at 0.1 Tesla (T) [1]. Today’s physicians are faced with a key issue in clinical neurology: many distinct CNS diseases are characterised by nearly identically appearing white matter changes and brain lesions that are often unspecific in appearance, limiting the diagnostic value of conventional MRI. Germany 5Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité Universitaetsmedizin Berlin, Charitéplatz 1, 10117
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