Abstract
A novel method was developed for the one-pot synthesis of ultrafine poly(lactic-co-glycolicacid) nanoparticles (PLGA NPs), using an emulsion solvent evaporation formulationmethod. Using either cetyltrimethylammonium bromide (CTAB) or poly(ethyleneglycol)-distearyl phosphoethanolamine (PEGPE) as an oily emulsifier during the emulsionprocess, produced PLGA particle sizes of less than 50 nm, constituting a breakthrough inemulsion formulation methods. The yield of ultrafine PLGA NPs increased withPEGPE/PLGA ratio, reaching a plateau at around 85%, when thePEGPE/PLGA ratio reached 3:1. The PEGPE–PLGA NPs exhibited high drug loading content, reducedburst release, good serum stability, and enhanced cell uptake rate compared withtraditional PLGA NPs. Sub-50 nm diameter PEG-coated ultrafine PLGA NPs show greatpotential for in vivo drug delivery systems.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
