Ultrafiltration Process Yield Study on Aqueous Solution of Total Ginsenosides

Abstract

Ultrafiltration membrane separation is a technology used to separate large and small molecules in solution by using the principle of membrane screening. This technology can retain the effective components of traditional Chinese medicine extract, remove macromolecular impurities and endotoxin, and meet the requirements of high quality, high efficiency, and low pollution in the modern production of traditional Chinese medicine. The study investigated the impact of 100 KDa molecular weight prepared from different ultrafiltration membrane on the ginsenosides ingredient composition of ginsenosides Rg1, ginsenoside Re, ginsenoside Rf, ginsenoside Rb1, ginsenoside Rg2, ginsenoside Rc, ginsenoside Rb2, ginsenoside Rb3, ginsenoside Rd and ginsenoside Rg3. Changes in retention rates were compared by the component changes in high-performance liquid chromatography in the volume concentrates, par volume of water constant volume diafiltration and 50% ethanol constant volume diafiltration ultrafiltration process. The results demonstrate that the 100 K cellulose ultrafiltration membrane was used for ginsenosides ultrafiltration. The yield and retention were superior to those of the polyethersulfone ultrafiltration membrane with the same molecular weight cutoffs.