Abstract
Chemical exchange saturation transfer (CEST) and magnetization transfer (MT) have become widely popular techniques for generating enhanced MRI contrast in vivo and ex vivo.[1] In order to fully characterize these phenomena, and to investigate suitable candidates for contrast agents, the polarization of the reporter signal (typically water) is measured as a function of the frequency offset of the saturating RF irradiation (Z-spectrum).[2] Here, we present an ultrafast method to obtain a Z-spectrum over a large range of frequency offsets from only two signal excitations. This method can be useful for fast screening of imaging phantoms and para- and diamagnetic CEST contrast agents under different experimental conditions (saturation time, power, etc).
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