Ultrafast Membrane Protein Dynamics Revealed by X-Ray Scattering with a Femtosecond Free-Electron Laser

Thomas D Grant,Suchithranga M.D.C Perera,Leslie A Salas-Estrada,Andrey V Struts,Udeep Chawla,Steven D.E Fried,Nipuna Weerasinghe,Kostantinos Karpos,Domingo Meza,Nadia A Zatsepin,Alan Grossfield,Derek Mendez,Petra Fromme,Richard A Kirian,Michael F Brown

doi:10.1016/j.bpj.2020.11.1006

Ultrafast Membrane Protein Dynamics Revealed by X-Ray Scattering with a Femtosecond Free-Electron Laser

Thomas D Grant, Suchithranga M.D.C Perera + Show 13 more

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https://doi.org/10.1016/j.bpj.2020.11.1006

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Journal: Biophysical journal	Publication Date: Feb 1, 2021
License type: publisher-specific-oa

Affiliation: University at Buffalo, State University of New York, University of Arizona, University of Rochester, Arizona State University, La Trobe University, Lawrence Berkeley National Laboratory

#X-ray Free-electron Lasers #Femtosecond Time Regimes + Show 8 more

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Abstract

The development of ultrafast X-ray free-electron lasers (XFELs) gives a new avenue to experimentally investigate protein dynamics in the picosecond and femtosecond time regimes. The XFEL beam of the LCLS has a very high peak X-ray brightness, which is key for probing elusive ultrafast structural changes during the biological function of protein molecules. With XFELs, femtosecond time-resolved small- and wide-angle X-ray scattering (TR-SWAXS) experiments afford unprecedented opportunities in membrane biophysics.

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