Abstract
The knowledge of frequency and temperature dependent dielectric properties of tissue is essential to develop ultra-wideband diagnostic technologies, such as a non-invasive temperature monitoring system during hyperthermia treatment. To this end, we characterized the dielectric properties of animal liver, muscle, fat and blood in the microwave frequency range from 0.5 GHz to 7 GHz and in the temperature range between 30 °C and 50 °C. The measured data were modeled to a two-pole Cole-Cole model and a second-order polynomial was introduced to fit the Cole-Cole parameters as a function of temperature. The parametric model provides access to the dielectric properties of tissue at any frequency and temperature in the specified range.
Highlights
Electromagnetic waves in the microwave frequency range offer a possibility to examine a non-transparent medium under test (MUT), because they are capable of penetrating a variety of materials, including biological tissues, without ionization
Muscle and blood as high water content tissues and fat as a low water content tissue
50 ◦ C in steps of 1 ◦ C by a temperature probe connected to a high precision thermometer
Summary
Electromagnetic waves in the microwave frequency range offer a possibility to examine a non-transparent medium under test (MUT), because they are capable of penetrating a variety of materials, including biological tissues, without ionization. The dielectric properties determine how electromagnetic waves propagate within the MUT The knowledge of these properties is essential for a wide variety of medical applications such as microwave breast cancer imaging [1,2,3,4,5,6] or microwave ablation and temperature monitoring [7,8,9,10,11]. The latter scenario is a promising approach to monitor the temperature distribution inside of the body during thermal therapies (e.g., hyperthermia), which support oncological treatments (e.g., chemotherapy or radiotherapy). The approach of microwave temperature monitoring is based on the temperature dependent dielectric properties of tissue
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