Abstract
Objectives: Polycystic ovary syndrome (PCOS) is the most frequent cause of female infertility, affecting about 4% to 8% of women in the age of procreation. For evaluation the protective effects of omega-3 polyunsaturated fatty acid on ovarian structure in experimental PCO induced by estradiol-valerat, this research was done. Materials and Methods: Wistar female rats (n=40) were allocated into four groups, one control (n=10) and three test groups (n=30), that one group received omega-3 (60 mg/rat/orally/daily), second and third groups were induced PCO by single injection of estradiol-valerate (16mg/ kg/ i.m), third group also received omega-3 (240 mg/kg) for 60 consequence days. Animals were kept in standard conditions. On day 60, the ovarian tissue of Rats in whole groups were removed and prepared for pathological analysis. Results: vacuolated area and rough endoplasmic reticulum expanded, de-granulated, disorganized were seen in PCO groups; however, these side effects decreased in the groups that received omega-3 significantly (p<0.05) in comparison to experiment groups and ovarian weights in PCO experimental decreased significantly (p<0.05). Conclusion: Results revealed that administration of omega-3 could significantly treat PCO. This suggested that polyunsaturated fatty acid could diminish negative side effects of PCO on ovary tissue. 1 Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2Department of Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran. Article History: Received 1 October 2013 Accepted 3 February 2014 Revised 15 January 2014 Available online 4 February 2014 Corresponding Author: Arash Khaki, Department of Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran. Tel: +989143138399 Email: arashkhaki@yahoo.com
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