Abstract
Microvessel imaging is useful for cancer diagnosis and treatment evaluation, neural functional imaging (through the neurovascular coupling effect), and evaluation of inflammatory diseases. High frame rate ultrasound imaging combined with more advanced tissue clutter filter can greatly improve the sensitivity of Doppler for micro-flow imaging. Examples in healthy human kidney, bowel of patients with Crohn's disease, and activation of animal brain and spinal cord in response to electrical stimulus will be presented. A second technology (with contrast agent), which achieves super-resolution microvessel imaging by tracking the centers of individual microbubbles, can resolve microvessels with size below 50 μm in a freely breathing rabbit with several millimeters of breathing motion. The principles of these imaging technologies will be presented with preliminary in vivo results.
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