Abstract
Resistant schizophrenia is a significant public health issue due to high treatment costs and institutional dependence of patients. Despite the various definitions currently available to define resistant schizophrenia, along with existing clinical guidelines, their impact on daily clinical practice remains limited. While clozapine has been endorsed by national clinical guidelines, its utilization remains suboptimal, with delays in initiation and instances of ineffectiveness. Ultra-resistant schizophrenia is defined by clozapine's inefficacy even after a well-conducted treatment. The relationship between epilepsy and epilepsy-related psychoses is intricate. Individuals with epilepsy are more likely to develop psychotic disorders, while those suffering from primary psychotic disorders also have an increased risk of epilepsy. These findings suggest the presence of shared predisposing factors. We present the case of a patient with clozapine-resistant schizophrenia associated with temporal epilepsy.
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