Abstract
We report a case of widespread unilateral drusen in a healthy 31 year old Caucasian woman using multi-modal imaging including ultra-high resolution optical coherence tomography (UHR-OCT). Dilated fundus exam showed multiple drusen-like lesions in the posterior pole without heme or fluid. Fundus auto fluorescence demonstrated hyperautofluorescent at the deposits. Fluorescein angiography revealed mild hyperfluorescence and staining of the lesions. Spectral-domain optical coherence tomography (SD-OCT) OS showed accumulations in the temporal macula at Bruch's membrane. UHR-OCT provided improved axial resolution compared to the standard 5 μm on the commercial SD-OCT and confirmed the presence of deposits in Bruch's membrane, consistent with drusen. The retinal layers were draped over the excrescences but did not show any disruption.
Highlights
Drusen was first described by Dr Franciscus Donders in 1855 via histopathological observations as round accumulations under the retinal pigment epithelium (RPE) in Bruch’s membrane [1]
In the Beaver Dam Offspring Study, soft drusen were seen in only 2% of patients age 21–34 [3]
We report a case of widespread unilateral drusen in a healthy 31 year old Caucasian woman
Summary
Drusen was first described by Dr Franciscus Donders in 1855 via histopathological observations as round accumulations under the retinal pigment epithelium (RPE) in Bruch’s membrane [1]. While a few drusen may occur in normal eyes, they are infrequently seen in patients under age 55 especially in large numbers [2]. In the Beaver Dam Offspring Study, soft drusen were seen in only 2% of patients age 21–34 [3]. When drusen occur in young adults, they are typically
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