Abstract
Chiral separation-methods development is usually very time-consuming, due to the diversity in chemical structures of pharmaceutical drug substances as well as the suitable separation conditions and the problem to choose the appropriate chiral selector. This paper shows an ultra-fast, capillary electrophoresis based screening procedure which was developed for chiral separation of several basic pharmaceuticals using dimethyl-β-cyclodextrin as chiral selector. Complete enantiomeric separations of basic drugs (metaproterenol and isoproterenol) were achieved as fast as in 40–50 s, with an R.S.D. for the absolute migration time reproducibility of less than 0.75%. The peak efficiency of the separations was usually over one million theoretical plates per meter, which correspond to an efficiency generation rate above 30 000 plates/m s.
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