Abstract
Upper gastrointestinal bleeding (UGIB) remains a major problem worldwide. Over time the management issues have changed and a paradigm shift occurred when it became clearly established that eradication of Helicobacter pylori would ”cure” peptic ulcers, including the elimination of new ulcers, recurrent ulcers, and ulcer complications. The subsequent recognition that H. pylori infections increased the risk of complications from nonsteroidal anti-inflammatory drugs (NSAIDs) led to the recommendation to test NSAID and aspirin users for H. pylori, and to eradicate the infection whenever it is found. Unfortunately, eradication of H. pylori is no longer straightforward, as clinicians are facing the increasing challenge of resistant strains. Moreover, eradication of H. pylori alone will not solve the problem of NSAID ulcer complications because NSAIDs themselves increase the risk of UGIB. Unresolved issues include identification of the circumstances in which particular traditional NSAIDs or cyclo-oxygenase-2 (COX-2)-selective inhibitors are preferred, and the actual role for gastroprotective co-therapy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
