UK Infantile Spasms Study: Effect of Time to Treatment and Age at Onset on Developmental Outcome

J Gordon Millichap

doi:10.15844/pedneurbriefs-25-8-4

Abstract

The effects of lead time to treatment (time from onset of spasms to start of treatment), age at onset of spasms, etiology, and treatment on developmental outcome at 4 years were investigated using multiple linear regression in 77 infants with spasms treated in the UK Infantile Spasms Study (UKISS).

Highlights

Researchers at the Hospital for Sick Children, Toronto, studied the interictal, ictal, and clinical findings on video-EEG in 12 children (11 female; mean age 4.9 years, range 1.5-9 years) with Jeavons syndrome (JS)
The effects of lead time to treatment, age at onset of spasms, etiology, and treatment on developmental outcome at 4 years were investigated using multiple linear regression in 77 infants with spasms treated in the UK Infantile Spasms Study (UKISS)
Outcome was significantly benefitted by steroid therapy in children whose spasms had no identifiable etiology (p=0.004)

Summary

Introduction

Researchers at the Hospital for Sick Children, Toronto, studied the interictal, ictal, and clinical findings on video-EEG in 12 children (11 female; mean age 4.9 years, range 1.5-9 years) with Jeavons syndrome (JS). The effects of lead time to treatment (time from onset of spasms to start of treatment), age at onset of spasms, etiology, and treatment on developmental outcome at 4 years were investigated using multiple linear regression in 77 infants with spasms treated in the UK Infantile Spasms Study (UKISS). Age of onset ranged from 2 months in 21 and not known in 6.

Results

Conclusion