Abstract
BackgroundUK Biobank’s ambitious aim is to perform cardiovascular magnetic resonance (CMR) in 100,000 people previously recruited into this prospective cohort study of half a million 40-69 year-olds.Methods/designWe describe the CMR protocol applied in UK Biobank’s pilot phase, which will be extended into the main phase with three centres using the same equipment and protocols. The CMR protocol includes white blood CMR (sagittal anatomy, coronary and transverse anatomy), cine CMR (long axis cines, short axis cines of the ventricles, coronal LVOT cine), strain CMR (tagging), flow CMR (aortic valve flow) and parametric CMR (native T1 map).DiscussionThis report will serve as a reference to researchers intending to use the UK Biobank resource or to replicate the UK Biobank cardiovascular magnetic resonance protocol in different settings.
Highlights
UK Biobank’s ambitious aim is to perform cardiovascular magnetic resonance (CMR) in 100,000 people previously recruited into this prospective cohort study of half a million 40-69 year-olds
A combination of various risk factors often leads to disease with each risk factor having only moderate effects that interact with each other in complex ways
The imaging visit includes a 35-min brain magnetic resonance imaging (MRI) scan at 3 Tesla, a dual energy X -ray absorptiometry (DEXA) scan (10–15 min), and carotid ultrasound (10–15 min) in addition to preparation and collection of non-imaging data and biological samples, and 20-min cardiovascular magnetic resonance (CMR) at 1.5 Tesla and 10-min abdominal MRI at 1.5 Tesla
Summary
UK Biobank’s ambitious aim is to perform cardiovascular magnetic resonance (CMR) in 100,000 people previously recruited into this prospective cohort study of half a million 40-69 year-olds. Understanding the determinants of diseases, such as myocardial infarction and stroke, is critical to advance medical knowledge that can lead to prolongation of life and improvement in quality of life. A combination of various risk factors often leads to disease with each risk factor having only moderate effects that interact with each other in complex ways. Prospective cohort studies allow insights into risk factors before disease develops or into how disease management affects participants
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