Abstract
Soursop fruit (Annona montana Macf.) is one of the plants can be used as as traditional medicine. This plant contains terpenoid and acetogenin which can cause toxicity. The fruit has a flavor that is tasteless so the innovation becomes probiotic drinks. This drink has been proven as an antioxidant, antibacterial, antihyperuricemia and antidiarrheal. The aim of this study was to know about acute toxicity of probiotic drink of soursop juice using brine shrimp lethality test method which will be indicated by LC50 value. This study used experimental methods conducted in the Laboratory of Farmakoknosi. There are several variations in concentration in this study, namely 10000 ppm, 20000 ppm, 30000 ppm, 40000 ppm, 50000 ppm, 60000 ppm, 70000 ppm, 80000 ppm and replication was done 3 times with total number of test animals used was 270. The results showed that probiotic drink of soursop juice can provide acute toxic effects on test animals with LC50 value of 29717,23 ppm. LC50 values indicate that the mountain soursop probiotic drink is not potentially toxic because it has a value of >1000 ppm.
Highlights
Buah sirsak gunung (Annona montana Macf.) mengandung senyawa metabolit sekunder terpenoid dan termasuk dalam antioksidan kuat dengan nilai IC50 61,93 ppm (Wulandari, 2017)
The results showed that probiotic drink of soursop juice can provide acute toxic effects on test animals with LC50 value of 29717,23 ppm
Pengaruh [19] Wahyuni, D.T., Widjanarko, S.B., 2015
Summary
Uji toksisitas akut minuman probiotik suatu gejala dan tingkat kematian. Penelitian sirsak gunung (Annona montana Macf.). Minuman probiotik sirsak analitik (Ohaus), kain saring, blender gunung (Annona montana Macf.) sebelumnya (Miyako), peralatan gelas (Pyrex), panci, sudah diteliti dan terbukti sebagai antioksidan termometer, incubator (Memmert IN30), oleh Wulandari (2017), antibakteri oleh Faizin kompor, lampu neon (Philips), lakban,. Bahan yang digunakan adalah buah sirsak alam adalah Brine Shrimp Lethality Test gunung (Annona montana Macf.) diambil dari (BSLT) (Setyowati and Cahyanto, 2016). Brine Shrimp Lethality Test (BSLT) Lactobacillus casei yang didapatkan dari merupakan suatu metode yang sering produk komersial, aquadest, larva udang digunakan sebagai skrining awal terhadap Artemia salina Leach didapatkan dari Fakultas senyawa aktif yang terkandung dalam Perikanan Universitas Muhammadiyah Malang tumbuhan, karena relatif murah, cepat dan dan air laut asli dengan pH 8-9. Leach yang berumur 48 jam karena memiliki dilakukan proses pembuatan minuman daya resistensi yang rendah terhadap probiotik dengan penambahan strain lingkungan (Refli, 2012). Selain itu hasil Lactobacillus casei dari produk komersial dan penelitian toksisitas menggunakan metode diinkubasi 24 jam
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