Abstract
Aim: Iohexol plasmaclearance is used as an indicator of kidney function in clinical and preclinical settings. To investigate the pharmacokinetic profile of iohexol, a rapid, simple method for measurement of iohexol in different matrices and species was needed. Materials & methods: Iohexol was separated on an Accucore C18 column(Thermo Fisher Scientific, CA, USA). Detection was performed on a Thermo Scientific Quantivatandem quadrupole mass spectrometer. The method was validated according to the requirements for bioanalytical methods issued by the USFDA and European Medicines Agency. Conclusion: We developed and validated a fast and efficient analytical method, suitable for analyzing iohexol in human EDTA plasma, human lithium-heparin plasma, human urine and goat-and pig EDTA plasma, using only one calibration line prepared in human EDTA plasma.
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