Abstract
UGT1A1 is the main metabolic enzyme for active product of Irinotecan (CPT-11).Its activity is closely related to the efficacy and adverse reactions of CPT-11.However,UGT1A1 * 28 gene polymorphism can significantly reduce the expression and activity of UGT1A1 enzyme.IP (irinotecan+cisplatin) program is the first-line chemotherapy of extensive stage small cell lung cancer,UGT1A1 * 28gene polymorphism may affect the efficacy and adverse reactions of IP program.So detecting UGT1A1 * 28gene polymorphism can guide individualized treatment of patients with small cell lung cancer. Key words: UGT1A1; Gene polymorphism; Small cell lung cancer; Irinoteca
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