UFASOMES: UNSATURATED FATTY ACID BASED VESICULAR DRUG DELIVERY SYSTEM

Arundhasree Arundhasree,Abhirami Rajendra Kumar,Aiswarya R,Sreelakshmi S Kumar,Sreeja C Nair,Rajalakshmi R

doi:10.22159/ijap.2021v13i2.39526

Arundhasree Arundhasree, Abhirami Rajendra Kumar + Show 4 more

Open Access

https://doi.org/10.22159/ijap.2021v13i2.39526

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Abstract

Various novel drug delivery systems have been developed encompassing several administration routes to deliver drugs at a rate decided as per the need of the body during the course of treatment and to achieve targeted therapy, also decreases undesirable side effects. Different types of vesicular drug delivery systems were developed, such as liposomes, niosomes, ufasomes etc. Ufasomes are unsaturated fatty acid vesicles which is a suspension of closed lipid bilayer formed from fatty acid and their ionized species having limited, narrow pH ranging from 7-9. Composition of fatty acid molecules is such that the hydrocarbon tails are pointed towards the inner core of the membrane and the carboxyl group are in touch with water. Stable ufasomes preparation mainly relies on appropriate choice of fatty acid, cholesterol quantity, range of the pH, buffer and lipoxygenase amount. Recent innovation provides very efficient features such as stability considerations, dynamic features and microscopic features of ufasomes. The article furthermore provides the difference between ufasomes with liposomes. For this review, the complete databases have been collected from various search engines such as researchgate, elsevier, pubmed, sciencedirect, google scholar, scopus etc., from the year 1965-2020 using the following keywords.

Highlights

In the developing delivery system, a novel drug delivery system has proved to be the most fulfilling and approachable to accomplish the targeted and controlled drug delivery
Colloidal carrier system is the other name of the particulate system which includes microspheres, lipid particles-high density lipoprotein (HDL) and low-density lipoprotein (LDL), polymeric micelles, nanoparticles and vesicular carriers such as liposomes, niosomes, ufasomes, ethosomes and so forth [5, 6]
Depending upon anionic fatty acid vesicles and didodecyldimethyl ammonium bromide (DDAB), major association (23 %) of vesicles with opposite charge was reported by Caschera et al [35]

Summary

INTRODUCTION

In the developing delivery system, a novel drug delivery system has proved to be the most fulfilling and approachable to accomplish the targeted and controlled drug delivery. Different novel methodology for delivering drugs by the vesicular system were developed, which includes liposomes, aquasomes, ethosomes, sphingosomes, bilosomes, transferosomes, virosomes, niosomes, ufasomes [9]. Transferosomes have high vesicle deformability which is its unique property and gives better penetration of intact vesicle and have both hydrophilic and hydrophobic properties They are stress-responsive and possess a complex vesicle with a complex lipid bilayer with an aqueous core [18] for the controlled and targeted delivery of drugs like peptides and hormones, transferases are predominantly used as carrier. Bilosomes are found to have increased bioavailability as they are readily absorbed from the small intestine and are carried to the portal circulation Through the hepatocirculation, they reach the liver and release the drug and is found to be effective in liver targeted drug delivery. Risk of atherosclerosis [32]

Method of preparation of ufasomes

Key issues in manufacturing ufasomes

Key findings

Findings

CONCLUSION