Abstract
Background/ObjectiveUncoupling proteins (UCPs) are located in the inner membrane of mitochondria. These proteins participate in thermogenesis and energy expenditure. This study aimed to evaluate how UCP1 and UCP3 expression influences substrate oxidation and elicits possible changes in body composition in patients submitted to bariatric surgery.Subjects/MethodsThis is a longitudinal study comprising 13 women with obesity grade III that underwent bariatric surgery and 10 healthy weight individuals (control group). Body composition was assessed by bioelectrical impedance. Carbohydrate and fat oxidation was determined by indirect calorimetry. Subcutaneous adipose tissue was collected for gene expression analysis. QPCR was used to evaluate UCP1 and UCP3 expression.ResultsObese patients and the control group differed significantly in terms of lipid and carbohydrate oxidation. Six months after bariatric surgery, the differences disappeared. Lipid oxidation correlated with the percentage of fat mass in the postoperative period. Multiple linear regression analysis showed that the UCP1 and UCP3 genes contributed to lipid and carbohydrate oxidation. Additionally, UCP3 expression was associated with BMI, percentage of lean body mass, and percentage of mass in the postoperative period.ConclusionsUCP1 and UCP3 expression is associated with lipid and carbohydrate oxidation in patients submitted to bariatric surgery. In addition, UCP3 participates in body composition modulation six months postoperatively.
Highlights
Obesity is a public health concern in many parts of the world because it has been associated with increased risk of developing hypertension and diabetes[1]
This study aimed to evaluate how UCP1 and UCP3 expression influences substrate oxidation and elicits possible changes in body composition in patients submitted to bariatric surgery
Multiple linear regression analysis showed that the UCP1 and UCP3 genes contributed to lipid and carbohydrate oxidation
Summary
Obesity is a public health concern in many parts of the world because it has been associated with increased risk of developing hypertension and diabetes[1]. Changes in lifestyle including diet modification and increased physical activity are strategies that aim at weight loss. These changes do not suffice in most cases, especially for individuals with severe obesity[3]. Bariatric surgery has been identified as the most useful tool to achieve weight loss and weight loss maintenance over time[4]. This procedure is recommended for individuals with body mass index (BMI) equal to or higher than 40 kg/m2 and with BMI higher than 35 kg/m2 when comorbidities exist[5]
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