Abstract
Ever since the discovery of ubiquitin in 1975[...].
Highlights
Several articles highlight the importance of ubiquitination in the regulation of intracellular signaling pathways and their cellular functions
UPS15 has two opposing functions: on the one hand, it has an oncogenic effect by activating TGF-β signaling and stabilizing the E3 ubiquitin ligase MDM2, but on the other hand, it acts as a tumor suppressor by negatively regulating the Wnt pathway through constitutive photomorphogenesis 9 (COP9) signalosome (CSN)-associated deubiquitination
The review article by Pergolizzi et al [11] for the first time summarizes the recent advances in G protein-coupled receptors (GPCRs) signaling in the social amoeba Dictyostelium discoideum and involvement of the ubiquitin system in its regulation
Summary
Several articles highlight the importance of ubiquitination in the regulation of intracellular signaling pathways and their cellular functions. Many studies have investigated the mechanism underlying the switch of TGF-β signaling from a tumor suppressor to an oncogene. Iyengar [4] reviewed the recent advances in elucidating the ubiquitin system’s role in regulating TGF-β signaling.
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