Abstract
About 70% of HCV-infected patients develop chronic hepatitis with significant progression to fibrosis, cirrhosis and hepatocellular carcinoma. Numerous attempts to create an efficient vaccine for the prevention of HCV-infection failed due to extremely high mutagenesis of HCV. However, recently, sufficient progress in the treatment of HCV-infection has been achieved with appearance of highly effective direct HCV antivirals as Sofosbuvir and Ledipasvir on the market [1,2]. Multiple clinical trials are in progress to demonstrate the efficiency of these new medications alone or in a combination with already known ribavirin and interferon alpha. However “the honeymoon period” with the successful treatment by direct antivirals may not be applied to HCV patients that drink alcohol since the pathogenesis of liver disease progression in these patients is different than in alcohol non-consuming HCV patients and requires the involvement of additional therapeutic strategies.
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