Abstract
Ubiquitin ligases join the field of dietary restriction in C.elegans
Highlights
Dietary restriction (DR) has been shown to robustly modulate organismal lifespan in multiple species
Carrano and colleagues report the discovery that an E2/E3 ubiquitin ligase set are required for the lifespan extending effects of DR in C.elegans [1]
The authors utilize C. elegans to look at E3 ubiquitin ligases of the conserved HECT (Homologous to E6-AP Carboxyl Terminus) family known to be important in tumorigenesis in mammals [2]
Summary
Dietary restriction (DR) has been shown to robustly modulate organismal lifespan in multiple species. Carrano and colleagues report the discovery that an E2/E3 ubiquitin ligase set are required for the lifespan extending effects of DR in C.elegans [1]. The authors utilize C. elegans to look at E3 ubiquitin ligases of the conserved HECT (Homologous to E6-AP Carboxyl Terminus) family known to be important in tumorigenesis in mammals [2].
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