Abstract
Ubiquitin C-Terminal Hydrolase L1 (UCHL1) is a de-ubiquitinating enzyme enriched in human and mouse oocytes. Studies of UCHL1 posit that it modulates activity of the epidermal growth factor receptor and overexpression leads to down-regulation of the estrogen receptor. UCHL1 also directly regulates protein stabilization and turnover in developing germ cells. Our lab has demonstrated that mice that are heterozygous or homozygous for UCHL1 deletion exhibit severe subfertility and aberrant ovulation, however the mechanism of these changes is not clear.
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