Abstract

\u201cCerebellar cognitive reserve\u201d: a possible further area of investigation

Highlights

  • The role of the cerebellum in cognitive functioning has traditionally received little attention, probably because it has always been mainly associated with motor functions

  • The topics discussed above raise an interesting question: why is it that while most of the human cerebellum is connected to brain networks important for cognition, clinicians and neuroimaging and neuropsychological researchers underestimate and pay little attention to the associated signs and symptoms? To the best of our knowledge, there are currently only one rating scale, no validated in Italy, designed by Hoche and colleagues in 2018 to test cerebellar cognitive capacities; and there is little in the way of a definition, and validation, of cerebellar atrophy scores

  • In light of the evidence reported above, an interesting focus of research appears to be the possible existence of a “cerebellar cognitive reserve”, which could be enhanced to provide protection against cognitive impairment, as already is Environmental sƟmulaƟon benefits mulƟple cogniƟve funcƟons and this is highly dependent on cerebellar circuits

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Summary

Introduction

The role of the cerebellum in cognitive functioning has traditionally received little attention, probably because it has always been mainly associated with motor functions. It has been shown that there is a close network of neural connections with reciprocal feed-forward and feed-back between the cerebellum and areas of the cerebral cortex connected with higher-order behaviors. It is well-known from the literature that these brain areas may be influenced by specific lifestyles, and the manifestation of clinical symptoms following brain atrophy may be delayed through an appropriate life intervention program. What about the cerebellum? Given the analogies and close connections described above, can we speculate that what happens in the brain happens in the cerebellum? The goal of this point of view is to draw attention to the possible

Brain reserve and cerebellar reserve
Cognitive cerebral reserve and a possible cerebellar cognitive reserve
Possible diagnostic and therapeutic approaches
Environmental enrichment improves cerebellum compensaƟon in case of damage
Compliance with ethical standards
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